STEINER, SOLOMON S.,POHL, RODERIKE,LI, MING,HAUSER, ROBERT
申请号：
PL10713742
公开号：
PL2403520T3
申请日:
2010.03.03
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection.
