The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate； a polyethylene glycol； β-cyclodextrin； ocyclodextrin； hydroxypropyl-β-cyclodextrin； sulfobutylether-β-cyclodextrin； lactose； benzyl alcohol； disodium succinate； propylene glycol； Cremophor EL； Dimethyl sulfoxide； D-mannitol； Trehalose； Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.
