SMNdelta7 Degron: Novel Compositions and Methods of Use

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专利权人:

Gideon Dreyfuss;Sungchan Cho

发明人:

Gideon Dreyfuss,Sungchan Cho

申请号：

US13510149

公开号：

US20120322852A1

申请日:

2010.11.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMNΔ7 degron and the encoded polypeptide. The invention also includes inhibitors of SMNΔ7 degron. The invention also includes compositions and methods for mitigating SMN deficiency by targeting inhibition of factors that mediate SMNΔ7-degron dependent degradation of SMNΔ7.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/