Therapeutic IL-13 polypeptides

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专利权人:

发明人:

Kenan Christopher Garcia,Ignacio Moraga Gonzalez

申请号：

US15353273

公开号：

US09732133B2

申请日:

2016.11.16

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13Rα2, relative to the native human IL-13 protein (b) altered affinity for IL-13Rα1 relative to the native human IL-13 protein (c) a disruption in the binding site for IL-4Rα relative to the native human IL-13 protein.

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