DERIVADOS DE 6, 7-DIHIDRO-5H-BENZO[7]ANULENOS, METODOS PARA SU PREPARACION, PREPARACIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU USO PARA LA PREPARACION DE MEDICAMENTOS
Relates to compounds of formula (i) wherein: R1, R2, R3 and R4 are independently H or F R5, R6 and R7 are independently h, F, CL, BR, Ethyl, among others X is alkyl (C1 - C6), cicloalquil (C3, C8) alquenilo (C2 - C6), alquilcarbonil (C1 - C6)Among others, and is optionally substituted alkyl (c1-c4) or cycloalkyl (C3 - C8) perfluorinated and partially perfluorinated M is an integer of 4 to 7 n is an integer from 1 to 6, p is an integer from 0 to 2 Q is an integer from 0 to 6.Preferred compounds are: 8 - (3,5-difluorophenyl) - 9 - [6 - (Methyl 3 - [(4,4,5,5,5 {-} pentafluoropentil) sulfonyl] amino] propyl] - 6.7 - hexyl) - 5h benzo [Cancel] - 7 - 3 - ol n - (6 - [4 - (4 - 4-fluorophenyl) - 3 - hydroxy - 6.7 - dihydro - 5h benzo [7] annulled - 9 - il] hexyl} - n {- 4 - [(4,4,4, - trifluorobutil) sulfonyl] butyl] - Beta Alanine. Others.These compounds are selective estrogen receptor modulators (SERMs) to be useful for the treatment of gynecological diseases, acne, osteoporosis, arteriosclerosisSE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1, R2, R3 Y R4 SON INDEPENDIENTEMENTE H O F R5, R6 Y R7 SON INDEPENDIENTEMENTE H, F, Cl Br, ETILO, ENTRE OTROS X ES ALQUIL (C1-C6), CICLOALQUIL (C3-C8), ALQUENILO (C2-C6), ALQUILCARBONIL (C1-C6), ENTRE OTROS OPCIONALMENTE SUSTITUIDOS Y ES ALQUILO (C1-C4) O CICLOALQUILO (C3-C8) PERFLUORADOS O PARCIALMENTE PERFLUORADOS m ES UN ENTERO DE 4 A 7 n ES UN ENTERO DE 2 A 6 p ES UN ENTERO DE 0 A 2 q ES UN ENTERO DE 0 A 6. SON COMPUESTOS PREFERIDOS: 8-(3,5-DIFLUOROFENIL)-9-[6-(METIL{3-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFONIL]PROPIL}AMINO)HEXIL]-6,7-DIHIDRO-5H-BENZO[7]ANULEN-3-OL N-{6-[8-(4-FLUOROFENIL)-3-HIDROXI-6,7-DIHIDRO-5H-BENZO[7]ANULEN-9-IL]HEXIL}-N-{4-[(4,4,4,-TRIFLUOROBUTIL)SULFONIL]BUTIL}-BETA-ALANINA ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES SELECTIVOS DEL RECEPTOR DE ESTROGENO (SERM) SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES GINECOLOGICAS, ACNE, OSTEOPOROSIS, ARTERIOESCLEROSIS
