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Controlled release peptide formulations
专利权人:
Camurus AB
发明人:
Tiberg, Fredrik,Nistor, Catalin,Johnsson, Markus
申请号:
AU2016202156
公开号:
AU2016202156B2
申请日:
2016.04.06
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
#$%^&*AU2016202156B220180322.pdf#####ABSTRACT The present invention relates to compositions forming a low viscosity mixture of: a) 20-80 wt.% of at least one diacyl glycerol and/or a tocopherol; b) 20-80 wt.% of at least one phosphatidyl choline (PC); c) 5-20 wt.% of at least one biocompatible, organic monoalcoholic solvent; d) up to 20 wt.% polar solvent e) at least one peptide active agent; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, and to prefilled administration devices and kits containing the formulations. 1001425311
来源网站:
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