University of Pittsburgh-of the Commonwealth System of Higher Education
发明人:
Ross, Ted M.,Carter Jr., Donald M.,Crevar, Jodi L.
申请号：
AU2013352179
公开号：
AU2013352179A1
申请日:
2013.11.27
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2012. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
