Method for regulating the condition of mammalian skin comprising the steps of applying a first personal care composition to an area of skin where regulation is desired, wherein the first personal care composition comprises at least one skin care active selected from the group consisting of niacinamide, salicylic acid, peptides, N-acetyl glucosamine, panthenol, butylated hydroxytoluene, N-acyl amino acid compounds, hexamidine, green tea, ascorbyl glucoside, hexanediol, pentanediol, a skin lightening agent, a heat shock protein potentiator, and mixtures thereof; and delivering energy to the area of skin by contacting the skin with an energy delivery device for a treatment period of at least 2½ minutes, wherein the energy delivery device comprises a skin-contacting surface that is controllably heatable to a temperature of from 37°C to 50°C.