Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (ARB) and neutral endopeptidase (NEP) inhibitor
Hu, Jiahui,Ruegger, Colleen,Kumaraperumal, Natrajan,Zannou, Erika Aina,Royce, Alan Edward,Al-Fayoumi, Suliman
申请号：
AU2008324878
公开号：
AU2008324878B2
申请日:
2008.11.04
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate]hemipentahydrate.
