CASTEEL, Melissa, Jean,DASHNER, Kathleen,JUNG, Hyuk-jun,SEO, Mun, Sik,SHI, Bing,WANG, Fang,ZIA, Vahid
申请号：
USUS2014/069123
公开号：
WO2015/099989A1
申请日:
2014.12.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)- 5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-4-fluoro-3-hydroxy-4- methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I) are described. Also provided are processes of making and methods of using the crystalline forms.L'invention concerne des formes solides cristallines du composé anti-VHC (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-méthyltétrahydrofuran-2-yl) méthoxy)(phénoxy)phosphorylamino)propanoate (composé I). L'invention concerne également des procédés de préparation desdites formes cristallines et des procédés d'utilisation de ces dernières.
