Tandem repeat DNA constructs producing proteins that attack plant pathogenic viruses, fungi and bacteria by disrupting transcription factors essential for replication thereof in plants
A method of conferring a plant with disease resistance to a pathogen, wherein the disease is mediated by a zinc finger protein of the plant or the pathogen, the method comprising the following steps: (a) exogenously adding to the plant, a pharmacologically active compound having the following structure: N Coo or a pharmacologically acceptable salt thereof, wherein RI, R2, R3 and R4 are selected from the group consisting of: a carboxyl group a methyl group ethyl group propyl group isopropyl group butyl group isobutyl group secondary butyl group tertiary butyl group pentyl group isopentyl group neopentyl group fluorine chlorine bromine iodine and hydrogen and (b) endogenously producing picolonic acid within the plant, wherein the plant is genetically transformed with a first promoter sequence operably linked to an encoded first picolinic acid carboxylase (PAC), the first promoter inducible by the pathogen characterised in that, upon pathogenic infection, both the endogenously produced picolinic acid and the exogenous compound synergistically inhibit the infected plants zinc finger proteins. Cassava 3vi~e~a S~I~4A2I+ Figure 09/09/10 va 18834 drw~s as filed 10sep 10
