The present invention discloses a process for forming a solution containing gold nanoclusters binding with ligands, the process comprises the following steps: provide a aqueous solution that comprises a gold precursor, a base and ligands ；perform a reduction reaction by adding a reductant into the aqueous solution to form a liquid containing gold nanoclusters binding with the ligands ；concentrate the liquid containing the gold nanoclusters binding with the ligands to a solid； dissolve the solid into water to form a crude solution； and perform a purification process by passing the crude solution through a membrane or a dialysis tube to obtain the solution containing the gold nanoclusters binding with the ligands.
