GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
SATHE, Rajendra S.,CLARK, William M.
申请号：
PE2016002765
公开号：
PE20170146A1
申请日:
2015.06.23
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a crystal form of (s) - 6 - ((1-acetylpyridine-4-il) amine) - N - (3 - (3,4-dihydroisoquinlin 2 (1H) - IL) - 2-hydroxypropyl) pyridine-4-carboxamida. Its X-ray powder derivative (drxp) has a property of 4.5 °.8.2 degrees10.4 degreesPage: 1Page: 116.4 degrees17.3 degrees17.7 degrees18.1%18.8 degreesPage: 120.8 degrees21.9 degrees23.3 + 0.2 degrees It also refers to the crystalline form of benzoate (s) - 6 - ((1-acetylpyridine-4-il) amine) - N - (3 - (3,4-dihydrocyanoquinol 2 (1H) - 1) - 2-hydroxypropyl) pyridine-4-amino amine. In addition, he refers to a pharmacology composer and a therapeutic approach. These crystal forms inhibit protein arginin methamphetamine transfer 5 (Prmt5),Useful in the treatment of cancerSe refiere a una forma cristalina de la sal succinato de (S)-6-((1-acetilpiperidin-4-il)amino)-N-(3-(3,4-dihidroisoquinolin 2(1H)-il)-2-hidroxipropil)pirimidino-4-carboxamida, cuyos patrones de difraccion de rayos X en polvo (DRXP) en cuanto a 2(theta) son: 4.5°, 8.2°, 10.4°, 13.5°, 15.8°, 16.4°, 17.3°, 17.7°, 18.1°, 18.8°, 19.6°, 20.8°, 21.9°, 23.3° y 24.0° ± 0.2°. Tambien se refiere a una forma cristalina de la sal benzoato de (S)-6-((1-acetilpiperidin-4-il)amino)-N-(3-(3,4-dihidroisoquinolin 2(1H)-il)-2-hidroxipropil)pirimidino-4-carboxamida. Ademas se refiere a una composicion farmaceutica y a un metodo de tratamiento. Dichas formas cristalinas inhiben la proteina arginina metiltransferasa 5 (PRMT5), siendo utiles en el tratamiento del cancer.
