A smart medicine box with volume detection includes an open-close structure, a first structure, an air pressure sensing module and a processor. The first structure is movably configured on the open-close structure, and a volumetric difference of a containing space inside the open-close structure is generated by the first structure moving in and out of the containing space. The air pressure sensing module is configured in the containing space for measuring a plurality of air pressure values in the containing space. When the medicine is took out from the containing space, the smart medicine box with volume detection in this present invention calculates the volume of the medicine by the difference of the volume and the air pressure, it not only can avoid the patient taking wrong medicine, but also can detect remain volume of the medicine and remind the patient to refill the medicine in the medicine box.一種具藥量偵測功能之智能藥盒包含一啟閉式結構、一第一結構、一氣壓感應模組以及一處理器。第一結構可動地設置於啟閉式結構，且藉由移入和移出啟閉式結構內的容置空間使容置空間之體積產生一體積定值差異。氣壓感應模組設置於容置空間，用以測量氣密空間中之複數個氣壓值。當病患取出藥時，本發明之具藥量偵測功能之智能藥盒藉由體積差異定值和氣壓變化計算出藥品之藥品體積，不僅能避免病患服用錯誤的藥種與藥量，並且能夠監控剩餘藥量與提醒病患補充藥盒內之藥量。
