BALKOVEC JAMES M.,THIERINGER ROLF,WADDELL SHERMAN T.
申请号：
IN6776/DELNP/2009
公开号：
IN277884B
申请日:
2009.10.22
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: or a pharmaceutically acceptable salt or solvate thereof wherein: 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom R1 and R2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R3 represents hydrogen or a fluorine atom or R1 represents methyl, R2 represents methyl or a fluorine atom and R3 represents a fluorine atom.
