TURECEK, PETER,SIEKMANN, JUERGEN,SCHEIFLINGER, FRIEDRICH,CANAVAGGIO, MICHEL
申请号：
CA2670618
公开号：
CA2670618C
申请日:
2007.12.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor Vila (F VHa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVlIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVlII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma.
