A fluid delivery system (400A) is generally directed to allowing fluid sources or other fluid delivery components to be reused with multiple fluid targets (318), and includes at least one fluid source (314) fluidly interconnectable with at least one sterilization zone (316) and at least one fluid target (318). This sterilization zone (316) could include one or more sterilization systems that attempt to neutralize contaminants entering the fluid delivery system (400A) by a backflow from the fluid target (318). One such sterilization system (500A-D) includes a container (502a-d) and a flush system (520) for sterilizing the container (502a-d) between uses. Another sterilization system (600) includes a flowpath (604) exposed to an output of an energy source (602) capable of destroying contaminants. Yet another sterilization system could include a sterilizing substance (710) that engages and moves along an interior surface (705) of a housing (704) to treat contamination thereon.