Sergio Paulo de Magalhães Simões;João Nuno Sereno de Almeida Moreira;Maria de Conceição Monteiro Pedroso de Lima;Vera Lúcia Dantas Nunes Caldeira de Moura
发明人:
João Nuno Sereno de Almeida Moreira,Vera Lúcia Dantas Nunes Caldeira de Moura,Sergio Paulo de Magalhães Simões,Maria de Conceição Monteiro Pedroso de Lima
申请号：
US14020592
公开号：
US20140004042A1
申请日:
2013.09.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.
