VARIABLE DOMAINS OF CAMELID HEAVY-CHAIN ANTIBODIES DIRECTED AGAINST GLIAL FIBRILLARY ACIDIC PROTEINS

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专利权人:

INSTITUT PASTEUR

发明人:

LAFAYE, PIERRE,BOURGEOIS, JEAN-PIERRE,ROUGEON, FRANCOIS

申请号：

CA2730268

公开号：

CA2730268C

申请日:

2009.07.10

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) di-rectedagainst an intracellular target and having an isoelectric point of at least8.5, for targeting said intracellular target or for thepreparation of a peptide vector. Particularly, it concerns VHH domainsdirected against a glial fibrillary acidic protein and usesthereof for preparing therapeutic or diagnostic agents.

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