The Trustees of Columbia University;Children's Hospital Medical Center
发明人:
Devarajan, Prased,Barasch, Jonathan M.
申请号：
ES10183320
公开号：
ES2754753T3
申请日:
2004.03.26
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.Un método para evaluar el grado de lesión renal en un sujeto, comprendiendo el método analizar la cantidad de NGAL en una muestra de orina del sujeto.
