Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a norovirus, with a nucleoside, a nucleotide and an analog thereof.本文揭示核苷、核苷酸及其類似物、包括核苷、核苷酸及其類似物中之一或多者之醫藥組合物及其合成方法。本文亦揭示利用核苷、核苷酸及其類似物改善及/或治療疾病及/或病況(包括諾羅病毒(norovirus)感染)之方法。