Systems for training an animal, such as a rodent, to maintain its head substantially motionless during an imaging procedure using an imaging and training system are disclosed. In some embodiments, the imaging and training system includes a frame defining an enclosure for enclosing an animal therein during the imaging procedure. The frame includes a head post that is attached to the head of the animal and a treadmill having a plurality of rollers that the animal is in operative contact such that one or more of the plurality of wheels rotate when the animal is in a walking motion and stop rotating when the animal is in a substantially motionless state. This arrangement trains the animal to remain substantially motionless when disposed within an imaging apparatus.
