Antimicrobial peptide was isolated and Purified from Gills of tilapia (Oreochromis niloticus)； Nucleic Acid encodes IT, composition containing same and their use for the control of pathogens as a molecular adjuvant and vaccine composition to enhance the immune response against the Antigen Vaccine.
The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia ( Oreochromis niloticus ) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.PEPTIDO ANTIMICROBIANO AISLADO Y PURIFICADO DE BRANQUIAS DE TILAPIA (Oreochromis niloticus)； ACIDO NUCLEICO QUE LO CODIFICA； COMPOSICION QUE LO COMPRENDE； Y SU USO PARA EL CONTROL DE PATOGENOS Y COMO ADYUVANTE MOLECULAR EN UNA COMPOSICION VACUNAL PARA AUMENTAR LA RESPUESTA INMUNE CONTRA EL ANTIGENO VACUNAL.
