ANTHONY B. WOOD,GREGORY J. ARCHAMBEAU,RICHARD L. WATSON
申请号：
BR112013003186
公开号：
BR112013003186A2
申请日:
2011.08.12
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
compositions and methods for treating cardiovascular disease. methods are provided for treating cardiovascular disease and related conditions and symptoms (e.g., cardiac arrhythmia, vascular disease, myocardial infarction, congestive heart failure, myocarditis, atherosclerosis and restenosis) comprising administering to a subject in need thereof a therapeutically effective amount of an electrokinetically altered aqueous fluid as described herein. in particular aspects, electrokinetically altered aqueous fluids comprise a predominantly stabilized charge oxygen-containing aqueous ionic nanostructures solution having an average diameter less than about 100 nanometers and sufficient to provide modulation of at least one cell membrane potential and membrane conductivity. cell phone. administration routes or formulations for electrokinetically altered fluids (e.g., gas-enriched electrokinetically altered fluids and solutions) and therapeutic compositions are presented, along with the use of electrokinetically altered aqueous fluids in surgical contexts including, but not limited to, related surgeries cardiovascular In addition, methods are provided for measuring biological activity of electrokinetically altered fluids.composições e métodos para tratamento de doença cardiovascular. são fornecidos métodos para tratar doenças cardiovasculares e condições e sintomas relacionados (por exemplo, arritimia cardíaca, doença vascular, infarto do miocárdio, isuficiência cardíaca congestiva, miocardite, aterosclerose e restenose) compreendendo administrar a um sujeito em necessidade dos mesmos uma quantidade terapeuticamente eficaz de um fluido aquoso eletrocineticamente alterado conforme descrito neste documento. em aspectos particulares, os fluidos aquosos eletrocineticamente alterados compreendem uma solução aquosa iônica de nanoestruturas contendo oxigênio de carga estabilizada predominantemente tendo um diâmetro médio menor que cerca de 100 nanômetros e suficiente para proporcio
