PURPOSE: A Campsis grandifolia K. Schum extract is provided to suppress the activities of human immunodeficiency virus (HIV) reversetranscriptase and glucosidase and HIV replication, thereby treating AIDS and preventing HIV infection.CONSTITUTION: A pharmaceutical composition for preventing virus contains a Campsis grandifolia K. Schum extract. The extract is a water soluble extract or an alcohol extract. Alcohol includes 10-100% ethanol or 10-100% methanol. The extract is prepared from Campsis grandifolia K. Schum leaves, stems, flowers, petals, and roots. An HIV transcriptase inhibitor contains the extract.COPYRIGHT KIPO 2013[Reference numerals] (AA) Leaf water extract (BB) Leaf methanol extract (CC) Stem water extract (DD) Stem methanol extract (EE) Concentratoin (ug/ml)본 발명은 HIV 억제 활성을 갖는 능소화 추출물 및 이를 유효성분으로 함유하는 AIDS 치료제에 관한 것이다. 본 발명의 능소화 추출물은 HIV 역전사효소 활성 억제, 프로테아제 활성 억제, 글루코시다제 활성 억제 및 HIV 증식 억제 활성이 뛰어나므로 AIDS를 치료하고, 진행을 억제시키고, 감염을 억제하는데 유용하게 사용될 수 있다.