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SUSPENSIONS OF NANOPARTICLES CONTAINING A CARBOXYVINYL POLYMER
专利权人:
ЛТД. (US);АЛЬКОН РИСЕРЧ
发明人:
ЧОВХАН Масуд А. (US),ГХОШ Малай (US),АСГХАРИАН Бахрам (US),ХАН Уэсли Вехсин (US)
申请号:
RU2012127675/15
公开号:
RU2012127675A
申请日:
2010.12.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Ophthalmic compositions of a water-based suspension for topical application, containing: carboxyvinyl polymer in a concentration of from 0.1 to 0.5% (wt./about.), Galactomannan in a concentration of from 0.1 to 0.4% (weight. / vol.); borate in a concentration of from 0.4 to 2.0% (weight./vol.); a moderately soluble particulate compound, the aforementioned compound having a solubility in water at 25 ° C. of 0.001 to 0.1% (w / v) and a particle size of 50 to 700 nm. 2. The composition according to claim 1, additionally containing a means for adjusting the pH in an amount sufficient to ensure that the composition has a pH from 5.0 to 7.2.3. The composition according to claim 1, additionally containing a means for regulating the tonicity in an amount sufficient that the composition has an osmolality of 250 to 350 mOsmol / kg. The composition according to claim 1, in which the above poorly soluble compound in the form of particles is nepafenac in a concentration of from 0.1 to 1.0% (wt./about.). The composition according to claim 1, wherein the aforementioned carboxyvinyl polymer is a carbomer at a concentration of 0.4% (w / v). The composition according to claim 1, further comprising a grinding agent in a concentration of from 0.005 to 0.1% (w / v). The composition of claim 6, wherein said grinding means is a surfactant or polymer. The composition of claim 7, wherein said grinding aid is sodium carboxymethyl cellulose. The composition of claim 1, further comprising a tonicity control agent, which is a metal chloride salt. The composition according to claim 9, wherein said metal chloride salt is sodium chloride at a concentration of 0.4% (w / v). The composition according to claim 1, complementary1. Офтальмологические композиции суспензии на водной основе для местного применения, содержащие:карбоксивиниловый полимер в концентрации от 0,1 до 0,5% (вес./об.);галактоманнан в концентрации от 0,1 до 0,4% (вес./об.);борат в концентрации от 0,4 до 2,0% (вес./об.); иумеренно
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