The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin;The University Of Queensland
发明人:
O'NEILL, Luke,COLL, Rebecca,COOPER, Matthew,ROBERTSON, Avril,SCHRODER, Kate,MACLEOD, Angus Murray,MILLER, David John
申请号：
HK18116654
公开号：
HK1257569A1
申请日:
2018.12.27
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se； J is S or Se； W1 and W2, when present, are independently selected from N and C； R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted； and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.
