Olaf Kinzel;Philip Jones;Federica Ferrigno;Laura Llauger Bufi;Carsten Schultz-Fademrecht;Giovanna Pescatore
发明人:
Philip Jones,Olaf Kinzel,Giovanna Pescatore,Laura Llauger Bufi,Carsten Schultz-Fademrecht,Federica Ferrigno
申请号：
US12227513
公开号：
US08188084B2
申请日:
2007.05.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula I:and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
