Frank Bedu-Addo,Greg Conn,Siva K. Gandhapudi,Martin Keough,Angela Mohs,Ritu Patel,Shweta Singh,Martin Ward,Jerold Woodward
申请号：
US15775680
公开号：
US20180353599A1
申请日:
2016.11.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention covers the use of certain classes of lipids including cationic lipids in ex-vivo dendritic cell therapies. The cationic lipids enhance antigen uptake, processing and presentation of the processed antigens by dendritic cells to CD8+ and CD4+ T-cells via the MHC classes I and II presentation pathways respectively. Antigen uptake via cationic lipid by dendritic cells result in significant lowering of the population of the immune suppressive regulatory T cells in the tumors and a significant increase of the tumor targeting cytotoxic T-cells. Loss of regulatory T cells and increase of tumor specific cytotoxic cells are conducive to effective elimination of the tumors.
