The present invention relates a brain targeted therapeutic delivery system, more particularly to a brain targeted therapeutic delivery system comprising an active agent incorporated in particulate carrier, surface of which is functionalized using glutathione. The glutathione is either conjugated or absorbed or adsorbed to the surface of particulate carrier by suitable technique. The present invention also relates to the process for preparing brain targeted therapeutic delivery system, its administration to the mammals and method of detection of the same in the brain and other body organ.
