FORMULATIONS STABLES D'ANTICORPS ANTI-RECEPTEUR DE MORT PROGRAMMEE 1 (PD-1) ET LEUR UTILISATION

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

SHARMA, MANOJ K.,BENJAMIN, WENDY,MITTAL, SARITA,BASARKAR, ASHWIN,NARASIMHAN, CHAKRAVARTHY NACHU,KASHI, RAMESH S.,SHAMEEM, MOHAMMED,BHATTACHARYA, SOUMENDU,FORREST, WILLIAM P., JR.,KRISHNAMACHARI, YOGIT

申请号：

CA3062160

公开号：

CA3062160A1

申请日:

2018.05.01

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The invention relates to stable formulations of antibodies against humanprogrammed death receptor PD- 1, or antigenbinding fragments thereof. In some embodiments the formulations of theinvention comprise between 5-200 mg/mL anti- PD-1 antibody,or antigen binding fragment thereof. The invention further provides methodsfor treating various cancers with stable formulations ofthe invention. In some embodiments of the methods of the invention, theformulations are administered to a subject by intravenousor subcutaneous administration.

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