2-adamantyl-butyramide derivatives as selective 11β-HSD1 inhibitors

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专利权人:

Christine Charon;Caroline Leriche;Didier Roche;Denis Carniato;Liliane Doare

发明人:

Didier Roche,Denis Carniato,Liliane Doare,Christine Charon,Caroline Leriche

申请号：

US12520141

公开号：

US08183265B2

申请日:

2007.11.22

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

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