Todd Nicholas Erpelding,Ralf Seip,Christopher Stephen Hall,Balasundar Iyyavu Raju
申请号：
US14349496
公开号：
US20140243737A1
申请日:
2012.09.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Ultrasound mediated delivery (USMD), real-time quantitative feedback derived (S264) therefrom, and proceeding by the system based on the feedback all are, in some embodiments, operable automatically and without need for user intervention. USMD may occur in a clinical setting accompanied by assays (S276) or real-time feedback, or by means of a wearable device that, based on feedback, regulates USMD in real time. Optionally, the user is provided an indication (S281) as to progress or success, of a treatment. Electrodes (128) may be attached across tissue in which transient pores are produced via sonoporation in the USMD procedure, and in vivo measurement is taken of an electrical parameter responsive to permeability. Therapeutic agent (S202) may be administered after particles activated for sonoporation are cleared from the circulation, to avoid, when it might exist, adverse interaction between the particles and agent.
