The invention surprisingly found that an immunomodulatory protein from Ganoderma can promote neurite outgrowth, suggesting that the immunomodulatory protein from Ganoderma can treat and/or prevent neurological disorders. Accordingly, the invention provides a method for promoting neurite outgrowth, the method comprising exposing the neuron to an effective amount of an immunomodulatory protein derived from Ganoderma, or a recombinant or a composition thereof. The invention also provides a method for treating and/or preventing a neurological disorder, the method comprising administering an effective amount of an immunomodulatory protein derived from Ganoderma, or a recombinant or a composition thereof to a subject.本發明令人驚訝地發現靈芝(Ganoderma)免疫調節蛋白可促進神經突生長,表明該靈芝免疫調節蛋白可治療及/或預防神經病症。因此,本發明提供用於促進神經突生長之方法,該方法包含將神經元暴露至有效量之自靈芝衍生之免疫調節蛋白或其重組體或組合物。本發明亦提供用於治療及/或預防神經病症之方法,該方法包含將有效量之自靈芝衍生之免疫調節蛋白或其重組體或組合物投與個體。