De Staat der Nederlanden; vert. door de minister van VWS; Welzijn en Sport; Ministerie van Volksgezondheid
发明人:
Zariri, Afshin,Pupo Escalona, Elder,van der Ley, Peter André
申请号：
AU2017211975
公开号：
AU2017211975A1
申请日:
2017.01.27
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention relates to neisserial LPS having a tetra-acylated lipid A moiety, wherein the tetra-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it lacks one of the secondary acyl chains and lacks a primary acyl chain on the 3-position of the glucosamine at the reducing end of the lipid A moiety. The invention further relates to neisserial bacteria that have been genetically modified to reduce expression of either one of the endogenous
