Yong-Jian GENG,Rosalinda MADONNA,James T. Willerson
申请号：
US14995061
公开号：
US20160243167A1
申请日:
2016.01.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A major risk factor for ischemic heart disease is advanced age. In adult bone marrow and other tissues, the number and function of stem cells decline with aging. Telomerase reverse transcriptase (TERT) is a nuclear protein that decreases senescence. Myocardin (MYOCD) is a transcription factor for myogenesis. Thus a method is provided for the simultaneous delivery of the telomerase reverse transcriptase (TERT) and myocardin MYOCD genes that resuscitates mesenchymal stromal cells (MSCs) from aged adipose and bone marrow tissues by increasing their capacity for survival, proliferation, and differentiation. TERT+/MYOCD+ MSCs restores a capacity for repairing ischemic tissues via improved blood flow and revascularization.
