An oral appliance system for a human mouth comprises at least one maxillary appliance and at least one mandibular appliance that can be removably anchored to teeth of a maxilla and mandible, respectively. Respective biasing members are carried by the at least one maxillary appliance and the at least one mandibular appliance. When the at least one mandibular appliance is anchored to the human mandible and the at least one maxillary appliance is anchored to the human maxilla of a common jaw, the respective biasing members act between the at least one maxillary appliance and the at least one mandibular appliance to urge the at least one mandibular appliance inferiorly and anteriorly away from the at least one maxillary appliance with a force between about 250 grams at contact and about 1200 grams at contact.