AGENTS DE DÉGRADATION DE TYPE PETITE MOLÉCULE QUI RECRUTENT DCAF15

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专利权人:

Dana-Farber Cancer Institute; Inc.

发明人:

申请号：

EP18888578.4

公开号：

EP3723757A1

申请日:

2018.12.14

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Disclosed herein are protein-targeting chimeric molecules (PROTACs) that recruit a specific ubiquitin ligase, such as CRL4DCAFL to a chosen target protein, causing its degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

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