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Crystal of compound as c-Met kinase inhibitor and preparation method therefor and use thereof
专利权人:
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.;Advenchen Laboratories Nanjing Ltd.
发明人:
GONG, Feng,HUANG, Ticong,ZANG, Haishan,ZHANG, Shibo,ZHAO, Rui,LIU, Fei
申请号:
AU2019227391
公开号:
AU2019227391A1
申请日:
2019.03.01
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present application falls within the field of medicinal chemistry, relates to the crystal of a compound as a c-Met kinase inhibitor, and specifically relates to the crystal of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystal for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystal of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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