BURNS, CHRISTOPHER JOHN,HARTE, MICHAEL FRANCIS,PALMER, JAMES T.
申请号：
PL14181447
公开号：
PL2848610T3
申请日:
2007.11.15
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The present invention relates to pyridines or pyrazines that inhibit kinases. In particular the compounds of the invention inhibit members of the class III PTK receptor family such as FMS (CSF-1R), c-KIT, PDGFR², PDGFR± or FLT3 and KDR, SRC, EphA2, EphA3, EphA8, FLT1, FLT4, HCK, LCK, PTK5 (FRK), SYK, DDR1 and DDR2 and RET. The compounds of the invention are useful in the treatment of kinase associated diseases such as immunological and inflammatory diseases； hyperproliferative diseases including cancer and diseases involving neo-angiogenesis； renal and kidney diseases； bone remodeling diseases； metabolic diseases； and vascular diseases.
