Massachusetts Eye and Ear Infirmary;The Schepens Eye Research Institute, Inc.
发明人:
Vandenberghe, Luk H.,Maurer, Anna Claire
申请号：
AU2018265414
公开号：
AU2018265414A1
申请日:
2018.05.10
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
This disclosure describes and demonstrates the utility of a particular sequence motif within an Adeno-associated virus (AAV) capsid protein that enables the assembly-activating protein (AAP)-dependence of the AAV to be modified. Thus, this sequence motif can be use to address and alleviate at least one of the bottlenecks encountered in the production of virus vectors. In particular, this disclosure describes a minimal motif defined through a novel phenotype-to-phylogeny mapping method that can be used to modify the AAP dependence of a virus.
