A preventative or therapeutic method for porcine epidemic diarrhea, including: a first administration step in which a live vaccine for the porcine epidemic diarrhea virus and an adjuvant are administered to pigs either orally or nasally; and a second administration step in which an inactivated vaccine for the porcine epidemic diarrhea virus and an adjuvant are administered to pigs intramuscularly.一種豬流行性下痢之預防或治療方法,其包含將豬流行性下痢病毒之活疫苗與佐劑以經口投予及經鼻投予之任一者對豬投予的第一投予步驟;及將前述豬流行性下痢病毒之不活化疫苗與佐劑以肌肉內投予對前述豬投予的第二投予步驟。