DANIEL L. FLYNN,KAREN M. YATES,LAKSHMINARAYANA VOGETI,MICHAEL D. KAUFMAN,THIWANKA SAMARAKOON,TIMOTHY MALCOLM CALDWELL,WILLIAM C. PATT
申请号：
BR112015022263
公开号：
BR112015022263A8
申请日:
2014.03.14
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
abstract described are compounds of formula i formula i which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and / or pdgfr kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases. ______________________________________________________ summary n-acyl-n '- (pyridin-2-yl) ureas and analogues exhibiting anticancer and antiproliferative activities are described compounds of formula i formula i which find utility in the treatment of cancer, autoimmune diseases and metabolic disorders of bone by inhibition of c-fms (csf-ir), c-kit, and / or pdgfr kinases. These compounds also find utility in the treatment of other c-fms, c-kit, or pdgfr-mediated mammalian diseases.abstract described are compounds of formula i formula i which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and/or pdgfr kinases. these compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases. ______________________________________________________ resumo n-acil-n'-(piridin-2-il) ureias e análogos apresentando atividades anticâncer e antiproliferativas são descritos compostos de fórmula i fórmula i que encontram utilidade no tratamento de câncer, doenças autoimunes e distúrbios metabólicas do osso, através da inibição de c-fms (csf-ir), c-kit, e/ou quinases pdgfr. estes compostos também encontram utilidade no tratamento de outras doenças de mamíferos mediadas por c-fms, c-kit, ou quinases pdgfr.
