The present invention relates to a pharmaceutical combination for inducing one or more immune responses and/or for enhancing effectiveness of vaccination in the host, which is capable of inducing cross-protection against multiples strains and/or serotypes of a virus. In one embodiment, the pharmaceutical combination is able to generate protection in food producing animals, such as cattle, sheep, goats, swine and other cloven-hoofed animals with fewer vaccination campaigns. This universal vaccine comprises an inactivated virus with one or more of the following components: polynucleotides encoding viral peptides, polypeptides or proteins in different types of plasmids viral peptides, polypeptides and proteins synthetic viral peptides and polypeptides recombinant viral peptides, polypeptides and proteins virus-like-particles virus-like-particles derived from other viruses proteins used as a carrier or as molecular adjuvant fused to peptides, polypeptides and/or proteins derived from viruses adjuvants emulsifiers, molecular adjuvants and carrier systems.本發明涉及用於誘導一種或多種免疫反應和/或用於增強宿主中疫苗接種的有效性的藥物組合,並能夠誘導針對病毒的多個毒株和/或血清型的交叉保護。在一個實施例中,藥物組合可以在可食用動物如牛、綿羊、山羊、豬和其他偶蹄動物中以較少疫苗接種活動產生保護作用。本發明的廣效型疫苗包含滅活病毒及以下一種或多種成分:在不同類型質粒內編碼病毒肽、多肽或蛋白質的多核苷酸;病毒肽、多肽或蛋白質;病毒的人工肽或多肽;病毒的重組肽、多肽或蛋白質;病毒樣顆粒;衍生自其他病毒的病毒樣顆粒;蛋白質作為載體或分子佐劑,與衍生自一種或多種病毒的肽、多肽或蛋白質融合;佐劑;乳化劑,分子佐劑和載體體系。
