PROBLEM TO BE SOLVED: To provide a blood purification device configured to continuously determine a needle removal state of an artery-side puncture needle or a vein-side puncture needle, even when a body surface-side electrode is removed from a patient.SOLUTION: The blood purification device includes: an artery-side electrode D1 a vein-side electrode D2 a power supply 8 capable of applying an electric current via an artery-side puncture needle (a) and a vein-side puncture needle b punctured into a patient a body surface-side electrode D3 closely fitted to a body surface of the patient detection means 9 capable of acquiring a heart rate of the patient on the basis of an electric signal detected by the body surface-side electrode D3 monitoring means 10 capable of monitoring, in real time, the electric current flowing in the artery-side electrode D1 and vein-side electrode D2, and a change in impedance in a body of the patient detected by the detection means 9 and determination means 11 that can determine a needle removal state in which the artery-side puncture needle (a) or vein-side puncture needle b is removed from the patient on the basis of the change in the impedance as the monitoring object of the monitoring means 10.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2019,JPO&INPIT【課題】体表側電極が患者から外れても動脈側穿刺針又は静脈側穿刺針の抜針状態を継続して判定することができる血液浄化装置を提供する。【解決手段】動脈側電極D1と、静脈側電極D2と、患者に穿刺された動脈側穿刺針a及び静脈側穿刺針bを介して電流を流し得る電源8と、患者の体表に密着して取り付けられ体表側電極D3と、体表側電極D3で検出された電気信号に基づいて患者の心拍を取得し得る検出手段9と、動脈側電極D1又は静脈側電極D2を流れる電流、及び検出手段9で検出された患者の体内におけるインピーダンスの変化をリアルタイムに監視し得る監視手段10と、監視手段10の監視対象であるインピーダンスの変化に基づいて、動脈側穿刺針a又は静脈側穿刺針bが患者から離脱した抜針状態を判定可能な判定手段11とを具備したものである。【選択図】図1