您的位置: 首页 > 农业专利 > 详情页

C2orf18 AS TARGET GENE FOR THERAPY AND DIAGNOSTICS OF CANCER
专利权人:
ИНК. (JP);ОНКОТЕРАПИ САЙЕНС
发明人:
НАКАМУРА Юсуке (JP),НАКАГАВА Хидеваки (JP),НАКАЦУРУ Суити (JP)
申请号:
RU2010141742/10
公开号:
RU2010141742A
申请日:
2009.03.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method for detecting or diagnosing cancer in an individual, comprising the step of determining a test level of C2orf18 expression in a biological sample derived from an individual, where an increase in said level compared to a normal control level of C2orf18 indicates that said individual is suffering from cancer or is at risk its development, where the test level of expression of C2orf18 is determined using any method selected from the group consisting of:! (a) determination of C2orf18 mRNA,! (b) determining the protein encoded by C2orf18; and! (c) determining the biological activity of the protein encoded by C2orf18. ! 2. The method according to claim 1, where the specified increase corresponds to the test level of expression of C2orf18, which is at least 10% higher than the specified normal control level. ! 3. The method of claim 1, wherein said cancer is pancreatic cancer. ! 4. The method according to claim 1, where the expression level of C2orf18 is detected by determining the hybridization of the C2orf18 probe with a gene transcript in said biological sample originating from an individual. ! 5. The method according to claim 1, where the level of expression of C2orf18 is detected by determining the binding of the antibody against the protein encoded by the C2orf18 gene. ! 6. The method according to claim 5, where the antibody recognizes the epitope C2orf18, consisting of the amino acid sequence CRAAGQSDSSVDPQQPF (SEQ ID NO: 5) and / or AEESEQERLLGGTRTPINDAS (SEQ ID NO: 6). ! 7. The method according to claim 1, where the biological sample originating from the individual is a biopsy material. ! 8. A method for screening a candidate for the role of an agent for the treatment or prevention of cancer or a candidate for the role of agonists or antagonists of the C2orf18 polypeptide capable of inhibiting the growth of cancer cells, where1. Способ обнаружения или диагностики рака у индивидуума, включающий стадию определения тестируемого уровня экспрессии C2orf18 в
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充