CHEN, YI,KABARIA, NIMESH,WANG, KAI-ROY,XU, HUI,LEAMY, PATRICK,WAN, HUA,SUN, WENQUAN,HUANG, LI TING
申请号：
PL14776766
公开号：
PL3030272T3
申请日:
2014.09.05
申请国别(地区):
PL
年份:
2019
代理人:
摘要：
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
