Paiman Peter GHOROGHCHIAN,Gabriela ROMERO URIBE,Eric OSTERTAG
申请号：
US16097187
公开号：
US20190255191A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed are compositions for delivering gene editing molecules to a cell. Exemplary compositions comprise a micelle assembled from a plurality of triblock copolymers, wherein each triblock copolymer having at least one hydrophobic block, at least one hydrophilic block, and at least one poly(L-histidine) block, wherein: the at least one poly(L-histidine) block complexes with the at least one gene editing molecule； and the at least one poly(L-histidine) block is capable of a pH dependent release of the at least one gene editing molecule.
