PROCEDES DE TRAITEMENT UTILISANT DES NANOPARTICULES TRES PETITES POUR INDUIRE LA MORT CELLULAIRE DE CELLULES CANCEREUSES PRIVEES DE NUTRIMENTS PAR FERROPTOSE
CORNELL UNIVERSITY;MEMORIAL SLOAN KETTERING CANCER CENTER
发明人:
BRADBURY, MICHELLE S.,WIESNER, ULRICH,OVERHOLTZER, MICHAEL,SCHER, HOWARD,MA, KAI
申请号：
CA2985126
公开号：
CA2985126A1
申请日:
2016.05.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
