PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION;DONG-EUI UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
CHUNG, HAE YOUNG,정해영,MOON, HYUNG RYONG,문형룡,HA, YOUNG MI,하영미,PARK, YUN JUNG,박윤정,KIM, SEONG JING,김성진,KIM, HYE RIM,김혜림,KIM, SEONG MIN,김성민,KANG, KYUNG HWA,강경화,CHUNG, HAE YOUNGKR,MOON, HYUNG RYONGKR,HA, YOUNG MIKR,PARK, YUN JUNGKR,KIM, SEONG JINGKR,KIM, HYE RIMKR,KIM, SEONG MINKR,KANG, KYUNG HWAKR
申请号：
KR1020160025450
公开号：
KR1017329290000B1
申请日:
2016.03.03
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to novel barbiturate and thiobarbiturate derivatives and a composition for promoting hair growth using the same. According to the present invention, the barbiturate and thiobarbiturate derivatives, in an animal model, have shown to promote hair growth and have excellent effects on hair growth by promoting regulation of Wnt/-catenin and hair growth factor signaling and suppressing mechanism of apoptosis. Accordingly, the barbiturate and thiobarbiturate derivatives of the present invention may be used as a composition for promoting hair growth.본 발명은 신규한 바비투르산(Barbiturate) 및 싸이오바비투르산(thiobarbiturate) 유도체 및 이를 이용한 발모촉진용 조성물에 관한 것으로, 상기 바비투르산(Barbiturate) 및 싸이오바비투르산(thiobarbiturate) 유도체들은 동물모델에서 모발성장을 촉진할 뿐 아니라, Wnt/β-카테닌과 모발성장인자의 신호전달 조절을 촉진시키고 세포 사멸기전을 억제함으로써 모발의 생장을 촉진하여 우수한 발모 효과를 나타냄에 따라, 본 발명의 바비투르산(Barbiturate) 및 싸이오바비투르산(thiobarbiturate) 유도체는 발모촉진용 조성물로 사용될 수 있다.
